The museum's collections consist of approximately 91,000 objects, 2.65 million photographs, 1,700 metres of archive shelving and more than 140,000 books. 16,456 photographs were catalogued and 762 objects were registered in 2022.

The museum participates in several research projects led by various institutions, and itself leads two major projects supported by the Arts Council of Norway; The project "Knowledge Topography of Museums" (2018-2023) is supported by the Arts Council of Norway's museum program Research in Museums. The project "Sustainable Energy Narratives. Industrial Museums Meet the Climate Crisis" (2021-2024) is supported by the Arts Council of Norway's Community Role Program.

In addition to working on exhibitions and several book projects, three staff members have been pursuing doctoral studies:
The doctoral project Science, Identity and Belonging (SIB) - Co-designing with young people at a Science museum, a qualitative study of process , which was carried out at the School of Museum Studies, University of Leicester, was completed in 2022. The project explored how museums can be an active part of children and young people's learning world, in a series of participatory workshops.

The doctoral project The Hofgaard machine – an early Norwegian computer? was initiated at the Department of Historical Studies at NTNU in 2019. The project is based on an object in the museum's collection, which can shed new light on early computer history.

The doctoral project Between Experience and Science – The Creation of Modern Beer in Norway 1860-1890 was also started at the Department of Historical Studies at NTNU in 2019. The project is based on the museum's historical archive of Ringnes Brewery.

The Norwegian Museum of Science and Technology is responsible for the coordination and development of the National Museum Network for the History of Health and Medicine and the Network for the History of Technology and Industry. In addition, the museum participates in the Network for Knowledge Centres, the Network for Worker Culture and Working Life History, the Network for Photography, the Network for Music and Musical Instruments, the Contemporary Network and the Network for Women's History .

The Norwegian Museum of Science and Technology has been active in several international networks and collaborative projects. The museum is a member of Artefacts, an international museum network focusing on museum research in the history of technology and science. The National Medical Museum is a member of the International Association of Medical Museums and collaborates with the European Association for the History of Medicine and Health . The museum is an associated partner in the research project Museums and Industry: Long Histories of Collaboration, which was awarded support through a European research program in 2022 and will start in 2023.

The Friends of The Norwegian Museum of Science and Technology Association is formally independent of The Norwegian Museum of Science and Technology Foundation, and maintains its own accounts. Fifty percent of the paid membership fee goes to the museum, which amounted to NOK 304,375 in 2022. The Friends of the Association members have free admission to the museum. The personal membership of the association was 832 in 2022 and the number of corporate members was 5.

Frode Meinich is the museum director. The museum employed a total of 113 people and 70.4 man-years of work were performed in 2022. One work accident resulting in minor personal injuries was registered in 2022. Sickness absence was 6.6 percent. Work on health, environment and safety has been carried out in line with plan and budget. The museum does not conduct activities that pollute the external environment beyond what is permitted by laws and regulations.

The museum building was built in 1985 and today bears the marks of more than 35 years of wear and tear. Expenses for operation and necessary maintenance of the museum buildings in 2022 were NOK 11,065,110, which is 15.4 percent above budget.

The museum emphasizes gender equality, and there is equal pay for equal work. 69 of the employees were women and 44 were men. The museum has seven employees with an ethnic minority background. In its outreach work, the museum has a particular focus on accessibility. In 2022, the museum has, among other things, continued a project with outreach aimed at people with dementia, outside the museum's regular opening hours. The exhibition spaces are in most areas satisfactorily adapted for people with disabilities. A report on the museum's report under the Equality and Discrimination Act can be found in the museum's annual report.