The museum's collections consist of more than 91,000 objects, 2.9 million photographs, 1,700 metres of archive shelving and more than 140,000 books and journals. 57,841 photographs were catalogued and 421 objects were registered in 2025.

The museum participates in several research projects led by various institutions, and itself leads a larger project supported by the Directorate of Culture.

The project Sustainable Energy Narratives. Industrial Museums Meet the Climate Crisis (2021-2026) is supported by the Directorate of Culture's Social Role Programme and is led by The Norwegian Museum of Science and Technology. The project Active Collaboration for Sustainability Communication in Museums (2024-2027) is supported by the Directorate of Culture through the Active Collaboration programme - three-year projects and is led by the Museums of Akershus.

The book project Norwegian Photo History 1940 to 2011 is a collaboration with the Norwegian Folkemuseum, Preus Museum and the National Library, with support from the Norwegian Photographers' Association. The book Invisible Present was launched on October 15, 2025.

The research project Reduce – less plastic in everyday life is led by SIFO at OsloMet and is funded by the Research Council of Norway.

Two employees have been pursuing doctoral studies that are scheduled to be completed in 2025/2026; The doctoral project The Hofgaard machine – an early Norwegian computer? was initiated at the Department of Historical Studies at NTNU in 2019. The project is based on an object in the museum's collection, which can shed new light on early computer history.

The doctoral dissertation There is a lot of thought behind a glass of beer. The role of knowledge in the establishment of modern beer in Christiania in the period 1840-1890 was defended for the PhD degree at NTNU on December 19, 2025.

The Norwegian Museum of Science and Technology is responsible for coordinating and developing the National Museum Network for the History of Health and Medicine and the Network for the History of Technology and Industry. In addition, the museum participates in the Network for Science Centres, the Network for Workers' Culture and Working Life History, the Network for Photography, the Network for Music and Musical Instruments, the Contemporary Network and the Network for Women's History.

The Norwegian Museum of Science and Technology has been active in several international collaborations. The museum is a member of Artefacts, an international museum network focusing on museum research in technology and the history of science. The Artefacts conference 2025 was held at the museum in October. The museum participates in the European research project Museums and Industry: Long Histories of Collaboration, which started in 2023 and ended in 2025. The National Medical Museum is a member of the steering committee of the International Association of Medical Museums.

The Association of Friends of The Norwegian Museum of Science and Technology is formally independent of the Foundation The Norwegian Museum of Science and Technology , and keeps its own accounts. Fifty percent of the paid membership fee goes to the museum, which amounted to 535,125,- in 2025. The Association of Friends members have free admission to the museum. The personal membership of the association was 1,392 in 2025 and the number of corporate members was 7.

Frode Meinich is the museum director. The museum employed a total of 124 people and 76.1 man-years of work were performed in 2025. Two work accidents resulting in minor injuries were registered in 2025. Sickness absence was 6.4 percent. Work on health, environment and safety has been carried out in line with plan and budget. The museum does not conduct activities that pollute the external environment beyond what is permitted by laws and regulations.

The museum building was built in 1985 and today bears the mark of 40 years of wear and tear. Expenses for operation and necessary maintenance of the museum buildings in 2025 were 11,042,990,-, which is 27,510,- below budget. The electricity price is 1,597,439,- lower than budgeted. These funds have been reallocated to necessary maintenance, so that other operation and maintenance costs are 1,569,929,- above budget. Work on replacing old light sources with LED lighting has continued in 2025.

The museum emphasizes gender equality, and there is equal pay for equal work. 70 of the employees were women and 54 were men. The museum has eight employees with an ethnic minority background. In its outreach work, the museum has a particular focus on accessibility. In 2025, the museum has, among other things, continued a project with outreach aimed at people with dementia, outside the museum's regular opening hours. The exhibition spaces are in most areas satisfactorily adapted for people with disabilities. A report on the museum's report under the Equality and Discrimination Act can be found in the museum's annual report.