The museum's collections consist of approximately 91,000 objects, 2.65 million photographs, 1,700 shelf meters of archive and more than 140,000 books. 5,429 photographs were cataloged and 282 objects registered in 2023.

The museum participates in several research projects led by various institutions, and itself leads two larger projects supported by the Norwegian Directorate of Culture.

The project Museums' topography of knowledge (2018-2023), which is supported by the Directorate of Culture's museum program Research in museums, was completed in 2023. The project Sustainable energy narratives. Industrial museums meet the climate crisis (2021-2024) is supported by the Directorate of Culture's Community Role Programme.

The museum has participated in the research project The boundaries of private life: sociality and belonging in digital everyday life (2020-2024), led by the Department of Social Anthropology at UiO and funded by the Research Council of Norway.

Norwegian Photo History book project is a collaboration with the Norwegian Folk Museum, the Preus Museum and the National Library, with support from the Norwegian Photographers' Association, which will result in a book published by Forlaget Press in 2024.

The research project Reduce – less plastic in everyday life is led by SIFO at OsloMet and is funded by the Research Council of Norway.

Two employees have been doing doctoral studies;

Doctoral project The Hofgaard machine – an early Norwegian computer? was initiated at the Department of Historical Studies at NTNU in 2019. The project is based on an item in the museum's collection, which can shed new light on early computer history.

Doctoral project Between experience and science - the creation of modern beer in Norway 1860-1890 was also started at the Department of Historical Studies at NTNU in 2019. The project is based on the museum's historical archive after Ringnes Brewery.

The Norwegian Museum of Science and Technology is responsible for the coordination and development of the National Museum Network for the History of Health and Medicine and the Network for the History of Technology and Industry. In addition, the museum participates in the Network for Knowledge Centres, the Network for Worker Culture and Working Life History, the Network for Photography, the Network for Music and Musical Instruments, the Contemporary Network and the Network for Women's History .

The Norwegian Museum of Science and Technology has been active in several international networks and collaborative projects. The museum is part of Artefacts, an international museum network with a focus on museum research in the history of technology and science. The museum is an associated partner in the European research project Museums and Industry: Long Histories of Collaboration, which started in 2023. The project Framtidens tekniske museur is a development collaboration between Tekniska museet in Sweden, Denmark's Tekniske Museum and The Norwegian Museum of Science and Technology . The National Medical Museum is a member of the International Association of Medical Museums and collaborates with the European Association for the History of Medicine and Health .

The association The Norwegian Museum of Science and Technology 's friends is formally independent from The Norwegian Museum of Science and Technology Foundation, and keeps its own accounts. Fifty percent of the paid membership fee goes to the museum, which amounted to NOK 337,175 in 2023. Members of the Friends Association have free entry to the museum. The personal membership of the association was 959 in 2023 and the number of company members was 5.

Frode Meinich is museum director. The museum employed a total of 98 people and 68.0 man-years were carried out in 2023. There was one occupational accident that resulted in minor injuries in 2023. Sickness absence was 3.6 per cent. The work with health, environment and safety has been carried out in line with plan and budget. The museum does not operate activities that pollute the external environment beyond what is permitted by laws and regulations.  

The museum building was built in 1985 and today bears the marks of 40 years of wear and tear. Expenditure for operation and necessary maintenance of the museum buildings in 2023 was NOK 11,039,462, which is 28.3 per cent below budget. The reason for this is lower electricity prices than budgeted. Other operating and maintenance costs are in line with the budget.

Emphasis is placed on equality in the museum, and there is equal pay for equal work. 56 of the employees were women and 44 were men. The museum has seven employees with an ethnic minority background. In its dissemination work, the museum has a particular focus on accessibility. In 2023, the museum has, among other things, continued a project with dissemination aimed at people with dementia, outside of the museum's normal opening hours. In most areas, the exhibition premises are satisfactorily arranged for people with disabilities. A report on the museum's statement according to the Equality and Discrimination Act can be found in the museum's annual report.