The museum's collections consist of more than 91,000 objects, 2.9 million photographs, 1,700 metres of archive shelving and more than 140,000 books and journals. 2,054 photographs were catalogued and 403 objects were registered in 2024.

The museum participates in several research projects led by various institutions, and itself leads a larger project supported by the Directorate of Culture.

Prosjektet Bærekraftige energinarrativer. Industrimuseer møter klimakrisen (2021-2025) er støttet av Kulturdirektoratets Samfunnsrolleprogram og ledes av The Norwegian Museum of Science and Technology.

Prosjektet Aktiv samhandling for bærekraftformidling i museene (2024-2027) er støttet av Kulturdirektoratet gjennom programmet Aktiv samhandling – treårige prosjekter og ledes av Museene i Akershus.

Museet har deltatt i forskningsprosjektet Privatlivets grenser: sosialitet og tilhørighet i digitale hverdagsliv (2020-2024), ledet av Sosialantropologisk institutt ved UiO og finansiert av Norges forskningsråd.

Bokprosjektet Norsk fotohistorie 1940 til 2011 er et samarbeid med Norsk Folkemuseum, Preus museum og Nasjonalbiblioteket, med støtte fra Norges Fotografforbund, som skal resultere i en bok utgitt av Forlaget Press i 2025.

Forskningsprosjektet Reduce – mindre plast i hverdagen ledes av SIFO ved OsloMet og er finansiert av Norges forskningsråd.

Two employees have been pursuing doctoral studies that are scheduled to be completed in 2025;

Doktorgradsprosjektet Hofgaard-maskinen – en tidlig norsk datamaskin? ble innledet ved Institutt for historiske studier ved NTNU i 2019. Prosjektet tar utgangspunkt i en gjenstand i museets samling, som kan kaste nytt lys over tidlig datahistorie.

Doktorgradsprosjekt Opprettelsen av det moderne ølet i Christiania i perioden 1860-1890 ble også startet ved Institutt for historiske studier ved NTNU i 2019. Prosjektet tar utgangspunkt i museets historiske arkiv etter Ringnes Bryggeri.

The Norwegian Museum of Science and Technology is responsible for coordinating and developing the National Museum Network for the History of Health and Medicine and the Network for the History of Technology and Industry. In addition, the museum participates in the Network for Science Centres, the Network for Workers' Culture and Working Life History, the Network for Photography, the Network for Music and Musical Instruments, the Contemporary Network and the Network for Women's History.

The Norwegian Museum of Science and Technology har vært aktiv i flere internasjonale nettverk og samarbeidsprosjekter. Museet er med i Artefacts, et internasjonalt museumsnettverk med fokus på museumsforskning innen teknikk- og vitenskapshistorie. Museet deltar i det europeiske forskningsprosjektet Museums and Industry: Long Histories of Collaboration, som startet i 2023 og avsluttes i 2025. Nasjonalt medisinsk museum er medlem av styringskomiteen til International Association of Medical Museums.

The Friends of The Norwegian Museum of Science and Technology Association is formally independent of The Norwegian Museum of Science and Technology Foundation, and maintains its own accounts. Fifty percent of the paid membership fee goes to the museum, which amounted to NOK 385,000 in 2024. The Friends of the Association members have free admission to the museum. The personal membership of the association was 1,187 in 2024 and the number of corporate members was 6.

Frode Meinich is the museum director. The museum employed a total of 107 people and 71.5 man-years of work were performed in 2024. One work accident resulting in minor injuries was registered in 2024. Sickness absence was 6.1 percent. Work on health, environment and safety has been carried out in line with plan and budget. The museum does not conduct activities that pollute the external environment beyond what is permitted by laws and regulations.

The museum building was built in 1985 and today bears the marks of 40 years of wear and tear. Expenses for operation and necessary maintenance of the museum buildings in 2024 were NOK 9,699,706, which is 21.9 percent below budget. The reason for this is lower electricity prices than budgeted. Other operation and maintenance costs are in line with budget.

With support from Enova, the museum has replaced three ventilation systems, installed a heat pump and switched to LED lighting in large parts of the museum building in 2024. Total investment costs for the measures have been NOK 9,890,461, of which NOK 3,255,387 has been financed with support from Enova.

The museum emphasizes gender equality, and there is equal pay for equal work. 61 of the employees were women and 46 were men. The museum has eight employees with an ethnic minority background. In its outreach work, the museum has a particular focus on accessibility. In 2024, the museum has, among other things, continued a project with outreach aimed at people with dementia, outside the museum's regular opening hours. The exhibition spaces are in most areas satisfactorily adapted for people with disabilities. A report on the museum's report under the Equality and Discrimination Act can be found in the museum's annual report.